What are the benefits of taking PQQ for brain health?

PQQ supports cognitive function by promoting mitochondrial biogenesis (the growth of new mitochondria) in brain cells, which enhances energy production and may improve memory and focus. It also acts as a potent antioxidant, protecting neurons from oxidative stress linked to aging and neurodegenerative diseases. Some studies suggest PQQ may help reduce brain fog and support long-term cognitive health.

Can PQQ help with fatigue or low energy levels?

Yes, PQQ may combat fatigue by optimizing mitochondrial function—the energy powerhouses of cells—leading to improved ATP production. Unlike stimulants, it addresses energy at a cellular level, making it a sustainable option for those with chronic fatigue or sluggishness. Typical doses range from 10–20 mg daily, often combined with CoQ10 for synergistic effects.

Are there any side effects or risks of taking PQQ?

PQQ is generally well-tolerated, but high doses (above 20 mg/day) may cause mild headaches or digestive upset in sensitive individuals. Limited long-term safety data exists, so pregnant/nursing women and those on medications should consult a doctor. No severe adverse effects have been reported in clinical studies at standard doses.

How does PQQ compare to CoQ10 for mitochondrial support?

While both support mitochondria, PQQ uniquely stimulates the creation of new mitochondria (biogenesis), whereas CoQ10 primarily optimizes existing mitochondrial function. They work synergistically—many supplements combine them for enhanced energy and antioxidant benefits. PQQ may be more effective for cognitive support, while CoQ10 is better studied for heart health.

What’s the best time of day to take PQQ?

Morning or early afternoon is ideal, as PQQ’s energizing effects could interfere with sleep if taken too late. Taking it with a meal containing fats may improve absorption. Avoid pairing with caffeine if sensitive to overstimulation, as both enhance alertness.

Can PQQ interact with medications or other supplements?

PQQ has no known severe interactions but may theoretically enhance or prolong the effects of stimulants (e.g., ADHD medications) due to its energizing properties. It’s safe with most supplements but consult a doctor if taking antipsychotics or chemotherapy drugs, as its antioxidant effects could theoretically interfere with certain treatments.

Supplement guide Antioxidants

PQQ

PQQ (Pyrroloquinoline Quinone) is a vitamin-like compound that supports cellular energy production and mitochondrial function. It acts as a potent antioxidant and is often used to enhance energy levels and support cognitive health.

At a glance

Snapshot

Primary goal: Energy & cognition
Dosage range: 10-20 mg daily
Best time to take: Morning
Time to effect: 2-4 weeks
Common stacks: CoQ10, L-Carnitine, Omega-3s
Intake notes: Take with food for better absorption

Ranked picks

Top 3 Best PQQ Supplements

#1 NootroScore9.0

NATURE TARGET

NATURE TARGET CoQ10-200mg-Softgels + PQQ with Organic-Olive-Oil - High Absorption-Coenzyme-Q10 - Antioxidant-for-Heart-Health and Immune Support, Energy Production, 120 Servings

SoftgelOrganic-Olive-OilHigh Absorption

Quantity: 120 count
Potency: 200mg

$18.98$0.16/count

View product

#2 NootroScore9.0

Horbäach

Horbäach PQQ Supplement 40 mg | 120 Capsules | Maximum Strength | Non-GMO and Gluten Free Supplement | Pyrroloquinoline Quinone Disodium Salt

CapsuleMaximum StrengthNon-GMO

Quantity: 120 count
Potency: 40 mg

$19.79$0.16/count

View product

#3 NootroScore9.0

Generic

CoQ10-200mg-Softgels with PQQ, BioPerine & Omega-3, 120 Servings Coenzyme Q10(Ubiquinone) Supplement for High-Absorption, Powerful-Antioxidant, Support Heart & Energy-Production

SoftgelPQQBioPerine

Quantity: 120 count
Potency: 200mg

$19.99$0.17/count

View product

Top 10 PQQ Supplements

NATURE TARGET

NATURE TARGET CoQ10-200mg-Softgels + PQQ with Organic-Olive-Oil - High Absorption-Coenzyme-Q10 - Antioxidant-for-Heart-Health and Immune Support, Energy Production, 120 Servings

SoftgelOrganic-Olive-OilHigh Absorption

Quantity: 120 count
Potency: 200mg
NootroScore: 9.0
Price: $18.98$0.16/count

Buy

Horbäach

Horbäach PQQ Supplement 40 mg | 120 Capsules | Maximum Strength | Non-GMO and Gluten Free Supplement | Pyrroloquinoline Quinone Disodium Salt

CapsuleMaximum StrengthNon-GMO

Quantity: 120 count
Potency: 40 mg
NootroScore: 9.0
Price: $19.79$0.16/count

Buy

Generic

CoQ10-200mg-Softgels with PQQ, BioPerine & Omega-3, 120 Servings Coenzyme Q10(Ubiquinone) Supplement for High-Absorption, Powerful-Antioxidant, Support Heart & Energy-Production

SoftgelPQQBioPerine

Quantity: 120 count
Potency: 200mg
NootroScore: 9.0
Price: $19.99$0.17/count

Buy

NatureBell

NatureBell CoQ10 200mg with PQQ, 240 Veggie Capsules | Stable High Absorption Form – Antioxidant Support for Heart, & Energy Health – Extra Strength Coenzyme Q10 Supplement

CapsuleVegetarianHigh Absorption

Quantity: 240 count
Potency: 200mg
NootroScore: 9.0
Price: $19.99$0.08/count

Buy

Health Thru Nutrition

Health Thru Nutrition PQQ 20mg 120 Servings Pyrroloquinoline Quinone as PureQQ | Promotes Mitochondrial Biogenesis | Certified Vegan | Non-GMO Gluten Soy Free Capsules| Clean Label PQQ Supplement

CapsuleCertified VeganNon-GMO

Quantity: 120 count
Potency: 20mg
NootroScore: 9.0
Price: $18.99$0.16/count

Buy

DEAL SUPPLEMENT

DEAL SUPPLEMENT CoQ10 200mg & PQQ 200mcg, 240 Veggie Capsules – 2 in 1 Coenzyme Q10 Supplement for Better Absorption – Antioxidant Support for Energy, Brain, & Heart Health – Non-GMO

CapsuleNon-GMOVegetarian

Quantity: 240 count
Potency: 200mcg
NootroScore: 8.9
Price: $23.99$0.10/count

Buy

Toniiq

Toniiq 99%+ 20mg Supplement - Ultra High Purity PQQ 20mg Concentrated Formula - PQQ 20 mg 120 Capsules - Pyrroloquinoline Quinone Supplement - 1 Capsule Serving - Vegetarian Capsules

CapsuleVegetarian99%+ Ultra High Purity

Quantity: 120 count
Potency: 20mg
NootroScore: 8.9
Price: $24.97$0.21/count

Buy

Life Extension

Life Extension Super Ubiquinol CoQ10 with PQQ, CoQ10, PQQ, shilajit, heart health, cellular energy support, 8x better absorption, gluten-free, 100 mg, 30 softgels

Softgelgluten-freeheart health

Quantity: 30 count
Potency: 100 mg
NootroScore: 8.7
Price: $33.75$1.13/count

Buy

Health Thru Nutrition

Health Thru Nutrition PQQ 40mg 120 Servings Pyrroloquinoline Quinone as PureQQ | Promotes Mitochondrial Biogenesis | Certified Vegan | Non-GMO Gluten Soy Free Capsules| Clean Label PQQ Supplement

CapsuleCertified VeganNon-GMO

Quantity: 120 count
Potency: 40mg
NootroScore: 8.6
Price: $36.95$0.31/count

Buy

#10

Pure Encapsulations

Pure Encapsulations SR-CoQ10 with PQQ - Heart Health Support* - Sustained Release Technology - Antioxidants Supplement - Gluten Free, Vegetarian & Non-GMO - 60 Capsules

CapsuleGluten FreeVegetarian

Quantity: 60 count
Potency: N/A
NootroScore: 7.1
Price: $90.20$1.50/count

Buy

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Use and selection

Buying Guide

Everything you need to know to make an informed decision about PQQ

Why It Matters

PQQ is crucial for cellular energy production and mitochondrial function, acting as a powerful antioxidant. It supports cognitive health and enhances energy levels, making it vital for overall vitality and longevity.

How PQQ Helps You

Energy Support

PQQ enhances mitochondrial function, boosting cellular energy production and reducing fatigue by supporting ATP synthesis.

Cognitive Enhancement

PQQ promotes brain health by stimulating nerve growth factors (NGF) and protecting neurons from oxidative stress, improving memory and focus.

Antioxidant Protection

PQQ neutralizes free radicals more effectively than many antioxidants, reducing oxidative damage and supporting overall cellular health.

Frequently Asked Questions

Common questions about PQQ answered by our experts

What are the benefits of taking PQQ for brain health?: PQQ supports cognitive function by promoting mitochondrial biogenesis (the growth of new mitochondria) in brain cells, which enhances energy production and may improve memory and focus. It also acts as a potent antioxidant, protecting neurons from oxidative stress linked to aging and neurodegenerative diseases. Some studies suggest PQQ may help reduce brain fog and support long-term cognitive health.
Can PQQ help with fatigue or low energy levels?: Yes, PQQ may combat fatigue by optimizing mitochondrial function—the energy powerhouses of cells—leading to improved ATP production. Unlike stimulants, it addresses energy at a cellular level, making it a sustainable option for those with chronic fatigue or sluggishness. Typical doses range from 10–20 mg daily, often combined with CoQ10 for synergistic effects.
Are there any side effects or risks of taking PQQ?: PQQ is generally well-tolerated, but high doses (above 20 mg/day) may cause mild headaches or digestive upset in sensitive individuals. Limited long-term safety data exists, so pregnant/nursing women and those on medications should consult a doctor. No severe adverse effects have been reported in clinical studies at standard doses.
How does PQQ compare to CoQ10 for mitochondrial support?: While both support mitochondria, PQQ uniquely stimulates the creation of new mitochondria (biogenesis), whereas CoQ10 primarily optimizes existing mitochondrial function. They work synergistically—many supplements combine them for enhanced energy and antioxidant benefits. PQQ may be more effective for cognitive support, while CoQ10 is better studied for heart health.
What’s the best time of day to take PQQ?: Morning or early afternoon is ideal, as PQQ’s energizing effects could interfere with sleep if taken too late. Taking it with a meal containing fats may improve absorption. Avoid pairing with caffeine if sensitive to overstimulation, as both enhance alertness.
Can PQQ interact with medications or other supplements?: PQQ has no known severe interactions but may theoretically enhance or prolong the effects of stimulants (e.g., ADHD medications) due to its energizing properties. It’s safe with most supplements but consult a doctor if taking antipsychotics or chemotherapy drugs, as its antioxidant effects could theoretically interfere with certain treatments.